The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.

The 1996 Bernard B. Brodie lecture: A journey in cytochrome P450 and drug metabolism research.

I am very honored at being chosen as the recipient of the 1996 Bernard B. Brodie Award in Drug Metabolism and to join the ranks of the previous recipients of the award (Gillette, 1979; Coon, 1981; Jerina, 1983; Mannering, 1986; Nebert, 1986; Levin, 1990; Zeigler, 1991; Guengerich, 1993; Ortiz de Montellano, 1995). I wish to thank the American Society for Pharmacology and Experimental Therapeuti...

The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain.

Dr. Bernard Brodie's legacy is built on fundamental discoveries in pharmacology and drug metabolism that were then translated to the clinic to improve patient care. Similarly, the development of a novel class of therapeutics termed the soluble epoxide hydrolase (sEH) inhibitors was originally spurred by fundamental research exploring the biochemistry and physiology of the sEH. Here, we present ...

Escalation and the Nuclear Option

Teaching and learning in the interactive classroom.

The Claude Bernard Distinguished Lectureship of the Teaching of Physiology Section is presented annually at the Experimental Biology meeting. The lectureship is named for Prof. Claude Bernard, the experimental physiologist who is credited with introducing the concept of homeostasis. The 2006 Claude Bernard Distinguished Lecture was given by Dr. Dee U. Silverthorn from the University of Texas at...

Ascorbic Acid in Aromatic Hydroxylation I. a Model System for Aromatic Hydroxylation* by Sidney Udenfriend, Carroll T. Clark, Julius Axelrod, and Bernard

Studies in this laboratory on the conversion of tyramine to hydroxytyramine by homogenates of adrenal medulla showed that hydroxylation occurred maximally on the addition of ascorbic acid. Further investigation revealed that the hydroxylation did not require adrenal tissue, but could occur in the presence of ascorbic acid and oxygen. This observation led to a study of the r61e of ascorbic acid ...